The complex was built during the 12th century and belonged to the Hospital of Santa Maria della Scala in Siena.
Probably dating from the late Renaissance, is mentioned for the first time in a document from 1590.
The Church was later redesigned both externally and internally by the architect Giuseppe Partini in 1884, inspired by 16th-century models.
From it comes the statue of the Madonna attributed to Andrea della Robbia, from 1870 onwards preserved within the Church of our Lady of Vitaleta in the historical centre of San Quirico d’Orcia, said bought in 1553 in a shop in Florence.
The chapel of the Madonna Madonna is on a dirt road from Pienza, San Quirico d’Orcia and is placed under the UNESCO protection.